Exhibit 645 · Website

Rijksuniversiteit Groningen: Acetylcholine beyond bronchoconstriction; A regulator of inflammation and remodeling

Rijksuniversiteit Groningen

… in her thesis have revealed that acetylcholine contributes to airway inflammation and remodeling in asthma and Chronic Obstructive Pulmonary Disease (COPD) specifically via M3 muscarinic receptors. In addition, she provided the first evidence that inflammation in COPD is in part mediated by the neurotransmitter acetylcholine. …

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